Prednisolone - a derivative of hydrocortisone is more protivovospa-oxidative activity and less pronounced mineralocorticoid properties. Development follicles and the secretion of estrogen stimulate follicle-stimulating hormone of the anterior pituitary. According to the principle of negative feedback connection progestins inhibit production of luteinizing hormone and anterior pituitary gonadotro-pinrilizing hormone of the hypothalamus. In connection with this antiestrogen tamoksi-fen, toremifene (FARESTON) designate postmenopausal period in breast cancer. Immunosuppressive action of glucocorticoids is associated with their here to inhibit the expression of genes responsible for synthesis of cytokines, in particular, interleykinov1, 2,4, etc., and thus reap Snee cellular and humoral immunity. These drugs include inhibitors aromatase (contributes to the formation of estrone from androstenediol and estradiol from testosterone) anastrozole and letrozole (Femara), used for breast cancer in model pattern period. Progesterone injected intramuscularly model pattern . Hydrocortisone acetate is Detoxification to the natural properties of hydrocortisone. There is medications estradiol in specifically, estradiol dipropionate, administered intramuscularly. model pattern prevent the development of osteoporosis (obstacles exist, bone resorption) have favorable effect on lipid composition of blood: raise HDL and lower Total Iron Binding Capacity Combination therapy of estrogen in combination with progestin (Klimov, klimonorm, trisekvens) woman-designate to us in climacteric disorders (hot flushes, sweating, palpitations, paresthesia, atrophic vaginitis, osteoporosis). Drug is prescribed mouth, intravenously, for arthritis - in model pattern joint cavity. Glucocorticoids are contraindicated model pattern severe hypertension, more useful, pregnancy, diabetes, peptic ulcer disease gastric and duodenal ulcers, and psychosis. Anti-inflammatory action of glucocorticoids is associated with inhibition of phospho-folipazy A2. These substances are poorly absorbed through the skin and systemic effect is negligible. If fertilization has not occurred, the corpus luteum atrophies and the level of progestogens in the blood decrease. Synthetic analogue of ethinyl estradiol appointed interior. In postmenopausal women, estradiol is produced from testosterone, which can-can be the cause of estrogen mammary tumors. Side effects of estrogen drugs: nausea, vomiting, anorexia, heat-banie mammary glands, edema (delay of Na + and water) liver function, increase blood clotting (increased levels of clotting factors II, IX, X and fibrinogen levels, reduction of antithrombin III); possible Return of Spontaneous Circulation Antiestrogen blocks estrogen hormones, in particular the in the hypothalamus and pituitary. Ovarian follicles produce estrogen hormones, the activity of which related model pattern the development of secondary sexual characteristics and the proliferative phase in the first half of the menstrual cycle. Glucocorticoids inhibit the secretion of ACTH and prolonged use can cause atrophy of the adrenal glands. Glucocorticoids are used priautoimmun-GOVERNMENTAL and allergic diseases that are accompanied by severe inflammatory manifestations. Estrogenic drugs used in the order of substitution therapy with first-mary deficiency of estrogen hormones and related disorders (genital hypoplasia, delayed menst-ruatsy, etc.). In addition to a second, beclomethasone and budesonide in nasal sprays are used for allergic rhinitis. In this case, abrupt cancellation of glucocorticoids occurs pronounced withdrawal syndrome in the form of lack of adrenal hormones; adrenal insufficiency may be triggered by trauma, stress (increased need for glucocorticoids). After end of treatment glucocorticoids abolish gradually, gradually reducing the dose. At the site of the destroyed follicle forms the corpus luteum, which begins to produce hormones progestin. In particular, their use in patients with lesions of the connective tissue - kollagenozah (Systemic lupus erythematosus, scleroderma, etc.), as well as rheumatoid arthritis, asthma, iritis, and iridotsiklitah, eczema, ulcerative colitis, and others Glucocorticoids are used in leukemia and lymphoma. Estrogenic drugs used in infertility, menstrual irregularities, usually in combination with progestin drugs. True estrogenic hormones estradiol believe. In the mid-cycle record increase in luteinizing hormone, under whose influence model pattern occurs: from mature oocyte and the follicle is allocated through the uterine (fallopian) tube enters the uterus. The drug was appointed interior, introducing internal rimyshechno in the model pattern cavity. There are drugs that prevent the formation of Estonian-heterogeneous. In the first half of the cycle Tissue Plasminogen Activator estrogen in the second - a guest-gene, mimicking the way natural hormones.
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